Endocrine Abstracts

Introduction: Alemtuzumab is an humanized monoclonal antibody used for treatment of Relapsing remitting Multiple Sclerosis (RRMS). One of its main adverse effects is thyroid dysfunction, being a fluctuating hypothyroidism the most frequent presentation. Sometimes this thyroid disturbance is so significant that it might lead to alemtuzumab withdrawal. We present two Clinical cases of hyperthyroidism secondary to alemtuzumab with different clinical courses. <p class="abstext...

Warthin-like variant of papillary thyroid carcinoma is a rare histologic variant of PTC; they resemble Warthin tumor of salivary gland, frequently associated with lymphocytic thyroiditis. There is scarce literature available regarding this tumor.Clinical case: In August 2019 a 51-year-old female patient sought consult because she complained of constant pain in the anterior surface of the neck. Medical background: arterial hypertension, she had no history...

Introduction: The clinical presentation of ectopic Cushing’s syndrome secondary to pheochromocytoma differs from the classic manifestations of these endocrinopathies separately. This cosecretion causes greater morbidity, requiring a complex preoperative preparation. We describe two clinical cases, a 46-year-old male with grade II overweight and a 65-year-old female with grade I obesity, both with a personal history of hypertension poorly controlled with 7 and 3 antihypert...

Background/aim: X-linked hypophosphatemia (XLH) is a rare disease characterized by low phosphate level. Scientific evidence points to link between hypophosphatemia and obesity in general population. The aim of our longitudinal observational study was to investigate the prevalence of obesity and associated factors in a large cohort of children with XLH.Patients/methods: We selected 172 XLH-children of 5-20 years (113 girls/59 boys). Anthropometric paramet...

Background: Vitamin D has several ‘noncalcemic’ implications, including effects on cell signaling and differentiation. Patients with gastroenteropancreatic (GEP) neuroendocrine tumors (NET) have an increased risk of vitamin D deficiency, due to the tumor itself, systemic therapies and abdominal surgery. However, data regarding vitamin D status are limited. Aim of this study was to evaluate 25-hydroxy-vitamin-D (25(OH)D) levels in GEP-NET patients and correlated them ...

Background: Insulin Lispro 200 units/ml is a concentrated rapid-acting mealtime insulin (MTI) available as a prefilled, disposable pen (IL200) indicated for adults who require >20 units/day of prandial insulin. In comparison with Insulin Lispro 100 unit/ml prefilled pen, IL200 permits the delivery of an insulin dose in half the injection volume [1] and a lower glide force [2]. This study aims to understand physicians’ reasons to prescribe IL200, as well as characteriz...

Patients with autoimmune thyroid diseases (AITDs) are likely to develop celiac disease (CD) among other autoimmune disorders. The prevalence of CD in general population is about 1–1.5% and the frequency of AITDs-CD association is about 1.2–4.8%. CD can be asymptomatic in adults. Our objectives were to determine the prevalence of CD in adult patients with AITDs and the presence of other endocrine and non-endocrine autoimmune diseases in a single center in Buenos Aires...

Introduction: McCune-Albright syndrome (MAS) consists of at least two of the following three conditions: polyostotic fibrous dysplasia (PFD), café-au-lait skin pigmentation and autonomous endocrine hyperfunction. The most common form of autonomous endocrine hyperfunction is precocious puberty, but other syndromes may be present, including acromegaly, hyperthyroidism, and Cushing syndrome. Acromegaly is seen in approximately 20% of patients with MAS. Treatment opt...

Objective: To evaluate changes in gut microbiota induced by treatment in patients with gestational diabetes mellitus (GDM) treated with insulin in comparison to those treated with metformin.Material and methods: Thirty-one patients with GDM not controlled by diet, included in MeDiGes study (‘Efficacy of metformin in gestational diabetes not controlled by diet in comparison to insulin’), were aleatorized to receive insulin (n=14) or met...

Introduction: Cushing’s syndrome (CS) is certainly one of the most challenging disorders to physicians due to the difficulties that often appear during its investigation. The diagnosis of CS involves two steps: confirmation of hypercortisolism and determination of its etiology. Biochemical confirmation of the hypercortisolemic state must be established before any attempt for differential diagnosis. Failure to do so will result in misdiagnosis, inappropriate treatment, and...